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    • 专利摘要:
    Cosmetic compositions The present invention relates to a cosmetic composition comprising: (a) approximately 0.1% to approximately 5% by weight of mentone compounds according to formula (ia) or (ib): and (b) approximately 99.9% to approximately 50% by weight of at least one body oil or wax and optionally (c) approximately 0 to approximately 25% by weight of at least one emulsifier and / or (d) approximately 0 to approximately 25%. % by weight of at least one active ingredient.
    公开号:BR112015002651B1
    申请号:R112015002651
    申请日:2013-08-01
    公开日:2019-08-27
    发明作者:Kalem Cécile；Brouard Denis；König Martina；Lange Sabine；Siegel Sven
    申请人:Symrise Ag；
    IPC主号:
    专利说明:

    Descriptive Report of the Invention Patent for COSMETIC COMPOSITIONS.
    Field of the Invention [1] The present invention belongs to the field of cosmetics and refers to new compositions that comprise selected compounds of menthol, with improved stability and increased sensory profile when applied to human skin.
    Background of the Invention [2] Typically, cosmetic compositions comprise a multiplicity of components. When examining the ingredient list for a medium night cream, you can find up to 20 positions, and there is a tendency to add as many ingredients as possible to address many different issues, all at the same time. In fact, for many consumers, the complexity of a composition equals benefits and, therefore, they accept high prices, as they also provide high performance. On the other hand, the more complex a composition becomes, the more difficult it is to prevent negative interactions between components from occurring. A major problem for cosmetic compositions, of course, especially for all types of emulsions, is still their stability, especially when they are subjected to difficult storage conditions, such as high or low temperatures.
    [3] Another object is related to the sensory profile. The spread, the sensation after application and the odor are important parameters that contribute to the overall appeal of a cosmetic formulation after application to the skin.
    [4] The faster the body oils are spread over the skin, the better the consumer's perception. The spreading compartment of a formulation - and therefore its sensory profile - is linked to the average particle size of the droplets in the
    2/56 composition. The smaller the droplets are, the faster the spacing is. Consequently, there is still a need for additives that allow shifting the average particle size distribution to smaller values.
    [5] In addition, offensive odor still poses a problem, especially for compositions containing high amounts of fatty materials. In general, formulators need a specific combination of fragrances so that the bad odor of a cosmetic formulation can be disguised. However, it would be advantageous to use a new additive that addresses this issue, while simultaneously solving the other problems mentioned above, especially spreading, feeling greasy on the skin after application and stability.
    [6] Therefore, the present invention aimed to identify a multifunctional additive for cosmetic formulations, which does not interact negatively with other ingredients, while improving the stability and the sensory profile of cosmetic compositions containing that additive.
    Description of the Invention [7] The purpose of the present invention is to provide cosmetic compositions, which comprise:
    (a) Mentone compounds according to Formula (Ia) or (Ib):
    and (b) at least one body oil (b1) and / or a wax (b2) and, optionally, (c) at least one emulsifier and / or (d) at least one active ingredient.
    3/56 [8] Surprisingly, it has been observed that the menthol ketals according to the present invention meet all the needs mentioned above simultaneously:
    The addition of menthol ketals improves the stability of cosmetic formulations even under difficult storage conditions;
    At the same time, the addition of menthol ketals in a cosmetic formulation can help to improve your sensory profile:
    - firstly, menthol ketals are capable of providing a refreshing sensation to the skin,
    - Menthol ketals lead to the formation of smaller droplets in the compositions. Due to the fact that the oil or water droplets are more finely divided, the sensation on the skin is improved. For example, the feeling of greasy skin after applying creams and lotions can be reduced in this way. Deodorants can also cause a smoother and more creamy feeling when applied to the skin;
    - Menthol ketals are also capable of reducing the bad odor of compositions with an intrinsically fatty smell.
    [9] Therefore, menthol kettles meet the need for so-called "ingredients with a true ability to perform multiple tasks simultaneously".
    Menthol ketals [10] Menthol ketals (component a) comprise two structures, namely Acetal / Glycerol L-Mentona (FEMA GRAS 3807) and Glycerol / DL-Mentone Ketal (FEMA GRAS 3808) and their mixtures . FEMA GRAS 3807 is available, for example, under the trademark Frescolat® MGA and INCI: Mentona Glycerin Acetal (Symrise AG) and belongs to a group of menthol derivatives that provide a refreshing sensation to the skin and mucous membranes. The produ
    4/56 to is especially suggested for applications in the areas of oral care, hair care, sun care, skin care, toiletries, pharmaceuticals, laundry and nutrition products and, above all, for chewing gums and drinks. Originally recommended as a cooling agent by Wrigley Co. (EP 0485170 B1), it is also suggested for non-therapeutic use in cosmetics (EP 0507190 B1, Haarmann & Reimer).
    Body oils [11] Suitable body oils (component b1) are, for example, Guerbet oils based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of C 6 -C acids 22 linear fatty acids with C 6 -C alcohols 22 linear or branched fatty acids or esters of C 6 -Ci 3 branched carboxylic acids with C 6 -C alcohols 22 linear or branched fatty acids, such as myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erateate stearyl, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearate oestearyl, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenate, miristate behenila stearate, behenila isostearate, behenila oleate, behenila behenate, behenila erucate, erucila myristate, erucila palmitate, erucila stearate, erucila isostearate, erucila oleate, and erucila behenate. Also suitable are esters of C 6 -C 22 linear fatty acids with al
    5/56 branched alcohols, especially 2-ethylhexanol, esters of Ci 8 C 38 - alkyl hydroxy carboxylic acids with C 6 -C 22 linear or branched fatty alcohols, especially dioctyl maleate, esters of linear fatty acids and / or branched with polyhydric alcohols (such as, for example, propylene glycol, dimerdiol or trimertriol) and / or Guerbet alcohols, triglycerides based on C 6 -Cio fatty acids, mixtures of mono / di / triglycerides based on C 6 acids - Ci 8 fatty, esters of C 6 -C 2 alcohols and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid, esters of C2-C12 dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, carbon 6 -Ο 2 2 alcohol carbonates linear and branched fatty, cp, p, for example, carbonate di caprilyl (Cetiol® CC), Guerbet carbonates, based on fatty alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of benzoic acid with linear and / or branched C 6 C22 alcohols (for example, Finsolv® TN), linear or branched, symmetrical or asymmetric dialkyl ethers having 6 to 22 carbon atoms per alkyl group, such as, for example, tipprilyl ether (Cetiol® OE), polyester epoxidated fatty acid ester ring opening products, silicone oils (cyclomethicone, methicone silicone grades, etc.), aliphatic or naphthenic hydrocarbons, such as squalane, squalene or dialkylcyclohexanes and / or mineral oils
    Waxes [12] Among the group of suitable waxes (component b2), it is possible to differentiate between the following types:
    • Super greasing agents, • Consistency factors, • Pearlescent waxes and
    6/56 • Natural waxes [13] Super greasing agents. Super greasing agents can be selected from substances such as, for example, lanolin and lecithin, in addition to polyethoxylated or acetylated derivatives of lanolin and lecithin, polyol esters of fatty acids, monoglycerides and fatty acid alkanolamides; fatty acid alkanolamides can also serve as foam stabilizers.
    [14] Consistency factors. The consistency factors can be, for example, fatty alcohols or hydroxylated fatty alcohols containing 12 to 22 and preferably 16 to 18 carbon atoms and also partial glycerides, fatty acids or hydroxylated fatty acids with the same range of carbons. A combination of these substances with alkyl oligoglycosides and / or N-methyl glucamides of fatty acids with the same chain length and / or polyglycerol poly-12-hydroxystearates is preferably used.
    [15] Pearlizing waxes. Suitable pearling waxes are, for example, alkylene glycols esters, especially ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglycerides; esters of polybasic carboxylic acids optionally hydroxy-substituted with fatty alcohols containing 6 to 22 carbon atoms, especially long chain esters of tartaric acid; fatty compounds, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes and fatty carbonates that contain a total of at least 24 carbon atoms, especially laurone and distearyl ether; fatty acids, such as stearic acid, hydroxystearic acid or behenic acid, oleophinic epoxide ring opening products containing 12 to 22 carbon atoms with fatty alcohols containing 12 to 22 carbon atoms and / or polyols containing 2 to 15 carbon atoms and 2 to 10 hydroxyl groups and their
    7/56 mixtures.
    [16] Natural waxes. In addition to the mineral oils used, waxes can also be present in the preparations, more especially natural waxes such as, for example, candelilla wax, carnalba wax, Japanese wax, esparto grass wax, cork wax, guarumã wax, wax rice oil, sugar cane wax, ouricuri wax, Montana wax, beeswax, shellac wax, spermaceti, lanolin (wool wax), uropigiana fat, ceresin, ozocerite (earth wax), petrolatum, paraffin waxes and microceras; chemically modified waxes (hard waxes), such as Montana ester waxes, Sasol waxes, hydrogenated jojoba waxes and synthetic waxes such as polyalkylene waxes and polyethylene glycol waxes.
    Emulsifiers [17] As an option, the compositions according to the present invention can also include emulsifiers (component c). Emulsifiers can be non-ionic, anionic, cationic and / or amphoteric in nature.
    [18] Especially preferred are non-ionic emulsifiers such as:
    • Products from the addition of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide to C 8 .22 linear fatty alcohols, to C12-22 fatty acids and alkyl phenols containing 8 to 15 carbon atoms in alkyl group;
    • C12 / 18 fatty acid monoesters and diesters of products from the addition of 1 to 30 moles of ethylene oxide to glycerol;
    • Glycerol mono and diesters and saturated and unsaturated fatty acid mono and diesters containing 6 to 22 carbon atoms and their products from the addition of ethylene oxide;
    • Products from the addition of 15 to 60 moles of ethylene oxide to castor oil and / or hydrogenated castor oil;
    8/56 • Polyol esters and especially polyglycerol esters such as polyglycerol polyvinyloleate, polyglycerol poly-hydroxystearate or polyglycerol isostearate / polyglycerol dimerate. Mixtures of compounds belonging to several of these classes are also suitable;
    • Products from the addition of 2 to 15 moles of ethylene oxide to castor oil and / or hydrogenated castor oil;
    • partial esters based on C 6 acid / 22 linear fatty acids, branched, unsaturated or saturated, ricinoleic acid and 12hidroxiesteárico and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (for example sorbitol), alkyl glucosides (for example, methyl glycoside, butyl glycoside, lauryl glycoside) and polyglycosides (for example, cellulose);
    • Mono, di and trialkyl phosphates and mono, di and / or tri-PEG-alkyl phosphates and their salts;
    • Wool wax alcohols;
    • Polysiloxane / polyalkyl polyether copolymers and corresponding derivatives;
    • Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol and / or mixed esters of C 6 .22 fatty acids, methyl glucose and polyols, preferably glycerol or polyglycerol, • Polyalkylene glycols and • Glycerol carbonate.
    [19] Products from the addition of ethylene oxide and / or propylene oxide to fatty alcohols, fatty acids, alkylphenols, glycerol mono and diesters and fatty acid mono and sorbitan diesters are known commercially available products . The products are homologous mixtures whose average degree of alkoxylation corresponds to the ratio between the amounts of ethylene oxide and / or propylene oxide and the substrate with which the addition reaction is carried out.
    9/56. The monoesters and diesters of C12 / 18 fatty acids of products from the addition of ethylene oxide to glycerol are known as lipid layer promoters for cosmetic formulations. The most preferred emulsifiers are described in more detail as follows:
    A. Partial glycerides [20] Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid monoglyceride, isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, monoglyceride acid diglyceride of ricinoleic acid, monoglyceride of linoleic acid, diglyceride of linoleic acid, monoglyceride of linolenic acid, diglyceride of linolenic acid, monoglyceride of erucic acid, diglyceride of erucic acid, monoglyceride of tartaric acid, diglyceride of tartic acid, diglyceride of tarty acid diglyceride of citric acid, monoglyceride of malic acid, diglyceride of malic acid and their technical mixtures which may also contain small amounts of triglyceride resulting from the manufacturing process. Products from the addition of 1 to 30 and preferably 5 to 10 moles of ethylene oxide to the aforementioned partial glycerides are also suitable.
    B. Sorbitan esters [21] Suitable sorbitan esters are sorbitan mono-stearate, sorbitan sesquiiso-stearate, sorbitan diisostearate, sorbitan triiso-stearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan dioleate, sorbitan triolate, triolate sorbitan, sorbitan sesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sesquiricinoleate, sorbitan dirricinoleate, sorbitan trirricinoleate, sorbitan monohydroxy stearate, sesquih
    10/56 bitane, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monitartrate, sorbitan sesquitartarate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monitrate, sorbitan sitrate, sorbitan ditritrate, sorbitan ditritrate, sorbitan dictitrate , sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate and their technical mixtures. Products from the addition of 1 to 30 and preferably 5 to 10 moles of ethylene oxide to the aforementioned sorbitan esters are also suitable.
    C. Polyglycerol esters [22] Typical examples of suitable polyglycerol esters are polyglyceryl dipolehydroxystearate-2 (Dehymuls® PGPH), polyglycerin-3-diisostearate (Lameform® TGI), polyglyceryl-4 iso-stearate (Isolan ® Gl 34), polyglyceryl-3 oleate, polyglyceryl-diisoestearoyl diisostearate (Isolan® PDI), polyglyceryl-methylglycoside-3 (Tego Care® 450), polyglyceryl-3 beeswax (Bellina® wax), polyglyceryl caprate-4 (polyglycerol caprate T2010 / 90), polyglyceryl-3-cetyl ester (Chimexane® NL), polyglyceryl distearate3 (Cremophor® GS 32) and polyglyceryl polyarricinoleate (Admul® WOL 1403), polyether glycerate and polyether glycolate their mixtures. Examples of other suitable polyesters include the mono, di and triesters of trimethylol propane or pentaerythritol with lauric acid, coconut fatty acids, tallow fatty acids, palmitic acid, stearic acid, oleic acid, behenic acid and the like, optionally reacted with acid 1 to 30 moles of ethylene oxide.
    D. Anionic emulsifiers [23] Typical anionic emulsifiers are C12-22 aliphatic fatty acids, such as palmitic acid, stearic acid or behenic acid, for example, and C12-22 dicarboxylic acids, such as azelaic acid or sebacic acid, for example .
    E. Amphoteric or zwitterionic emulsifiers
    11/56 [24] Other suitable emulsifiers are amphoteric or zwitterionic surfactants. Zwitterionic surfactants are active surface compounds that contain at least one group of quaternary ammonium and at least one carboxylate and sulfonate group in the molecule. Especially suitable zwitterionic surfactants are so-called betaines, such as N-alkyl-N, N-dimethylammonium glycinates, for example, coconut alkyl dimethylammonium glycinate, Nacylaminopropyl-N, N-dimethylammonium glycinates, for example, glycinate of coconut acylaminopropyl dimethylammonium, and 2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazolines containing 8 to 18 carbon atoms in the alkyl or acyl group and acylaminoethyl hydroxyethyl carboxymethyl glycinate. The starch derivative of fatty acids, known under the name CTFA of cocoamidopropyl betaine is especially preferred. Ampholytic surfactants are also suitable emulsifiers. The ampholytic surfactants are surface-active compounds which, in addition to group a C 8/18 alkyl or acyl, contain at least one free amino group and at least one -COOH- or -SO3H- group in the molecule and are capable of forming salts internal. Examples of suitable ampholytic surfactants are Nalkyl glycines, N-alkyl propionic acids, N-alkylamino butyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropyl glycines, N-alkyl taurines, N-alkyl sarcosines, 2-alkylaminopropionic acids and alkylamino acetic acids containing about 8 to 18 carbon atoms in the alkyl group. Especially preferred ampholytic surfactants are N-cocoalkylamino propionate, cocoacylaminoethyl aminoproprionate and C12 / 18 acyl sarcosine.
    Active ingredients [25] The compositions according to the present invention may contain additional ingredients encompassed by the term "active ingredients". Examples of suitable ingredients are surfactants, thickeners, polymers, silicone compounds, stabilizers, agents
    12/56 of primary and secondary protection against the sun, anti-dandruff agents, biogenic agents, film-forming agents, expanding agents, hydrotopes, preservatives, solubilizers, complexing agents, reducing agents, alkylating agents, perfume oils and dyes.
    A. Surfactants [26] Other auxiliaries and additives are anionic and / or amphoteric or zwitterionic surfactants. Typical examples of anionic surfactants are soaps, alkyl benzene sulfonates, alkane sulfonates, olefin sulfonates, alkyl ethers sulfonates, glycerol ethers sulfonates, methyl ester sulfonates, sulfograxic acids, alkyl sulfates, fatty alcohol ethers sulfates, glycerol ethers sulphate, fatty acid ethers sulphates, mixed ethers hydroxy sulphates, monoglyceride sulphates (ethers), fatty acid amide sulphates (ethers), mono and dialkyl sulphosuccinates, mono and dialkyl sulphosuccinates, sulphosiglycerides amides, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurates, N-acylamino acids such as acyl lactylates, acyl tartrates, acyl glutamates and acyl aspartates, alkyl oligoglycoside sulfates fatty acid proteins (especially wheat-based plant products) and alkyl (ether) phosphates. If they contain polyglycolic ether chains, anionic surfactants can have a conventional homologous distribution, although, preferably, this homologous distribution is in a narrow range. Typical examples of amphoteric or zwitterionic surfactants are alkyl betaine, alkyl starch betaine, aminopropionate, aminoglycinate, imidazolium betaine and sulfobetaine. The cited surfactants are well known compounds. Information on its structure and production can be found in relevant synoptic works, such as, for example, J. Falbe (ed.), “Surfactants in Consumer Products”, Springer Verlag, Berlin, 1987, pages 54 to 124 or J.
    13/56
    Falbe (ed.), “Katalysatoren, Tenside und Mineralõladditive (Catalysts, Surfactants and Mineral Oil Additives)”, Thieme Verlag, Stuttgart, 1978, pages 123-217. The percentage content of surfactants in the preparations can be 0.1 to 10% by weight and is preferably 0.5 to 5% by weight based on the preparation.
    B. Thickeners and rheological additives [27] Suitable thickeners are polymeric thickeners, such as those of the Aerosil® types (hydrophilic silicas), polysaccharides, more specifically xanthan gum, guar guar, agar-agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, in addition to relatively high molecular weight polyethylene glycol monoesters and diesters of fatty acids, polyacrylates (for example, Carbopols® [Goodrich] or Synthalens® [Sigma]), polyacrylamides, polyvinyl alcohol and polyvinylpyrrolidone, such as glycerides, eg fatty acid ethoxylates, fatty acid esters with polyols, for example, pentaerythritol or trimethylol propane, narrow range fatty acid ethoxylates and electrolytes such as sodium chloride and ammonium chloride.
    C. Polymers [28] Suitable cationic polymers are, for example, cationic cellulosic derivatives such as, for example, quaternized hydroxyethylcellulose which can be obtained from Amerchol under the name Polimer JR 400®, cationic starch, copolymers of diallylamine salts and acrylamides, quaternized vinylpyrrolidone / vinyl imidazole polymers such as, for example, Luviquat® (BASF), polyglycols and amines condensation products, quaternized collagen polypeptides such as hydroxypropyl collagen hydrolyzate of lauryl diamonium (Lamequat® L, Grünau) wheat quaternized polypeptides, polyethyleneimine, cationic silicone polymers such as amodimethicone, adipic acid copolymers and dimethylaminohydroxypropylethylene
    14/56 triamine (Cartaretine®, Sandoz), acrylic acid copolymers with dimethyl diallyl ammonium chloride (Merquat® 550, Chemviron), polyamino polyamides and their water-soluble cross-linked polymers, cationic chitin derivatives, such as quaternized chitosone optionally in microcrystalline distribution, condensation products of dihaloalkyls, for example, dibromobutane, with bis-dialkylamines, for example, bis-dimethylamino-1,3-propane, cationic guar gum such as Jaguar® CBS, Jaguar® C- 17, Jaguar® C-16 from Celanese, polymers of quaternized ammonium salts such as Mirapol®A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol and various types of polyquaternium (for example, 6 , 7, 32 or 37) that can be found on the market under the trade names of Rheocare® CC or Ultragel® 300.
    [29] Suitable anionic, zwitterionic, amphoteric and non-ionic polymers are, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, copolymers of methyl vinyl ether / maleic anhydride and its esters, non-cross-linked polyacrylic acids and cross-linked with polyols, acrylamidopropyl trimethylammonium / acrylate chloride copolymers; vinylpyrrolidone / vinyl acetate, vinipyrrolidone terpolymers / dimethylaminoethyl methacrylate / vincaprolactam and optionally ethers derived from cellulose and silicones.
    D. Silicones [30] Suitable silicone compounds are, for example, dimethyl polysiloxanes, methylphenyl polysiloxanes, cyclic silicones and silicone compounds modified with amino, fatty acids, alcohols, polyethers, epoxy, fluorine, glycosides and / or alkyls that can be liquid
    15/56 or resin type at room temperature. Other suitable silicone compounds are simethicone, which are mixtures of dimethicone with a chain length formed on average by 200 to 300 units of dimethylsiloxane and hydrogenated silicates. A detailed overview of suitable volatile silicones can be found in Todd et al. in Cosm. Toil. 91, 27 (1976).
    E. Primary sun protection factors [31] The primary sun protection factors in the context of the invention are, for example, organic substances (light filters) that are liquid or crystalline at room temperature and that are capable of absorbing radiation ultraviolet and to release energy in the form of radiation with a longer wavelength, for example heat.
    [32] The formulations according to the invention advantageously contain at least one UV-A filter and / or at least one UV-B filter and / or a broadband filter and / or at least one inorganic pigment. The formulations according to the invention preferably contain at least one UV-B filter or a broadband filter, more specifically preferably at least one UV-A filter and at least one UV-B filter.
    [33] Preferred cosmetic compositions, preferably topical formulations according to the present invention comprise one, two, three or more sun protection factors that are selected from the group consisting of 4-aminobenzoic acid and derivatives, derivatives of salicylic acid , benzophenone derivatives, dibenzoylmethane derivatives, diphenyl acrylates, 3-imidazol-4-yl acrylic acid and its esters, benzofuran derivatives, benzylidene malonate derivatives, polymeric UV absorbers containing one or more organosilicon radicals, derived from cinnamic acid, camphor derivatives, triamilino-s-triazine derivatives, 2-hydroxyphenylbenzotriazole cerivates, phenylbenzimidazole sulfonic acid derivatives
    16/56 and its salts, anthranilic acid menthol esters, benzotriazolic derivatives and indole derivatives.
    [34] Additionally, it is advantageous to combine compounds of Formula (I) with active ingredients that penetrate the skin and protect the skin cells from the inside against damage induced by sunlight and reduce the levels of skin matrix metalloproteases. The respective preferred ingredients, so called aryl hydrocarbon receptor antagonists, are described in WO 2007/128723, incorporated herein by reference in this patent application. Preferred is 2-benzylidene-5,6-dimethoxy-3,3-dimethylindan-1-one.
    [35] The UV filters mentioned below, which can be used within the context of the present invention, are preferred, but of course they do not include all.
    [36] The UV filters that are preferably used are selected from the group consisting of:
    • p-Aminobenzoic acid • ethoxylated p-aminobenzoic acid ethyl ester (25 mol) (INCI name: PEG-25 PABA) • p-dimethylaminobenzoic acid 2-ethylhexyl ester • N-propoxylated p-aminobenzoic acid ethyl ester (2 mol) • Glycerol ester of p-aminobenzoic acid • Homomenthyl ester of salicylic acid (homosalates) (Neo Heliopan® HMS) • 2-ethylhexyl ester of salicylic acid (Neo Heliopan® OS) • Triethanolamine salicylate • 4-Isopropyl benzyl salicylate • Anthranilic acid menthyl ester (Neo Heliopan® MA) • Diisopropyl cinnamic acid ethyl ester
    17/56 • p-Methoxycinnamic acid 2-ethylhexyl ester (Neo Heliopan®AV) • Diisopropyl cinnamic acid methyl ester • p-methoxycinnamic acid isoamyl ester (Neo Heliopan® E 1000) • Diethanolamine salt of p-methoxycinnamic acid • P-methoxycinnamic acid isopropyl ester • 2-Phenylbenzimidazole sulfonic acid and salts (Neo Heliopan® Hydro) • 3- (4'-trimethylammonium) benzylidene bornan-2one methyl sulfate • Beta-imidazole-4 acid ( 5) -acrylic (urocanic acid) • 3- (4'-sulfo) benzylidene bornan-2-one and salts • 3- (4'-methyl benzylidene) -D, L-camphor (Neo Heliopan® MBC) • 3- benzylidene-D, L-camphor • N - [(2 and 4) - [2- (oxoborn-3-ylidene) methyl] benzyl] acrylamide polymer • 4,4 '- [(6- [4- (1, 1-dimethyl) aminocarbonyl) phenylamino] -1,3,5triazine-2,4-diyl) diimino] -bis- (benzoic acid 2-ethylhexyl ester) (Uvasorb® HEB) • Benzylidene malonate polysiloxane (Parsol ®SLX) • Glyceryl ethylhexanoate dimethoxycinnamate • Sa dipropylene glycol lycylate • tris (2-ethylhexyl) -4,4 ', 4- (1,3,5-triazi na-2,4,6-tri-yltriimino) tribenzoate (= 2,4,6-trianilino - (p-carbo-2'-ethylhexyl-T-oxy) -1,3,5triazine) (Uvinul®T150) [37] Broadband filters which are preferably combined with one or more compounds of Formula ( I) in a preparation according to the present invention are selected from the group consisting of:
    18/56 • 2-Ethylhexyl-2-cyano-3,3-diphenyl acrylate (Neo Heliopan®
    303) • Ethyl-2-cyano-3,3'-diphenyl acrylate • 2-hydroxy-4-methoxybenzophenone (Neo Heliopan® BB) • 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid • Dihydroxy-4 -methoxybenzophenone • 2,4-dihydroxybenzophenone • Tetrahydroxybenzophenone • 2,2'-dihydroxy-4,4'-dimethoxybenzophenone • 2-hydroxy-4-n-octoxybenzophenone • 2-hydroxy-4-methoxy-4 '-methyl benzophenone • sodium hydroxymethoxybenzophenone sulfonate • 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone disodium • phenol, 2- (2H-benzotriazol-2-yl) -4- methyl-6- (2-methyl-3 (1,3,3,3tetramethyl-1 - (trimethylsilyl) oxy) disyloxyanyl) propyl) (Mexoryl® XL) • 2,2'-methylene-bis- (6- (2H -benzotriazol-2-yl) -4-1,1,3,3tetramethylbutyl) phenol) (Tinosorb® M) • 2,4-bis- [4- (2-ethylhexyloxy) -2-hydroxyphenyl] -1, 3,5-triazine • 2,4-bis - [{(4- (2-ethylhexyloxy) -2-hydroxy} phenyl] -6- (4-methoxyphenyl) -
    1,3,5-triazine (Tinosorb® S) • 2,4-bis - [{(4- (3-sulfonate) -2-hydroxypropyloxy) -2hydroxy} phenyl] -6- (4-methoxyphenyl) sodium salt -1,3,5-triazine • 2,4-bis - [{(3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy} phenyl] 6- (4-methoxypheni I) -1,3, 5-triazi na • 2,4-bis - [{4- (2-ethylhexyloxy) -2-hydroxy} phenyl] -6- [4- (2-methoxyethyl carbonyl) phenylamino] -1,3,5- triazi na • 2,4-bis - [{4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy} phenyl] 6- [4- (2-ethylcarboxyl) phenylamino] -1,3, 5-triazine
    19/56 • 2,4-bis - [{4- (2-ethylhexyloxy) -2-hydroxy} phenyl] -6- (1-methylpyrrol-2yl) -1,3,5-triazine • 2,4 -bis - [{4-tris- (trimethylsiloxy-silylpropyloxy) -2-hydroxy} phenyl] -6 (4-methoxyphenyl) -1,3,5-triazine • 2,4-bis - [{4- (2- metilpropenilóxi) -2-hydroxy} phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine • 2,4-bis - [{4- (T, T, T, 3, 5, 5, 5 , -heptamethylsiloxy-2methylpropyloxy) -2-hydroxy} phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine [38] UV-A filters which are preferably combined with one or more compounds from Formula (I) in a preparation according to the present invention are selected from the group consisting of:
    • 4-isopropyl dibenzoyl methane • Terephthalylidene dibornane sulfonic acid and salts (Mexoryl® SX) • 4-t-butyl-4'-methoxydibenzoyl methane (avobenzone) / (Neo Heliopan®357) • Disodium phenylene salt bis-benzimidazyl tetrasulfonic acid Neo Heliopan®AP) • 2,2- (1,4-Phenylene) -bis- (1 H-benzimidazole-4,6-disulfonic acid), monosodium salt • 2- (4-diethylamino-2- acid hexyl ester) hydroxybenzoyl) benzoic (Uvinul® A Plus) • Indanilidene compounds according to DE 100 55 940 A1 (= WO 2002 038537 A1) [39] The UV filters that are most preferably combined with one or more compounds of Formula (I) in a preparation according to the present invention are selected from the group consisting of:
    • P-aminobenzoic acid
    20/56 • 3- (4'-trimethylammonium) benzylidene bornan-2ona methyl sulfate • Salicylic acid homomenthyl ester (Neo Heliopan®HMS) • 2-hydroxy-4-methoxybenzophenone (Neo Heliopan®BB) • 2- Acid sulfonic phenylbenzimidazole (Neo Heliopan®Hydro) • Sulfonic terephthalylidene dibornane acid and salts (Mexoryl®
    SX) • 4-tert-butyl-4'-methoxydibenzoyl methane (Neo Heliopan® 357) • 3- (4'-sulfo) benzylidene bornan-2-one and salts • 2-Ethylhexyl-2-cyano- acrylate 3,3-diphenyl (Neo Heliopan® 303) • Polymer of N - [(2 and 4) - [2- (oxoborn-3-ylidene) methyl] benzyl] acrylamide • 2-Ethylhexyl ester of p-methoxykinnamic acid (Neo Heliopan® AV) • Ethyl ester of p-aminobenzoic acid (25 mol) ethoxylated (INCI name: PEG-25 PABA) • p-methoxyicinnamic acid isoamyl ester (Neo Heliopan® E1000) • 2,4,6-triamilino- (p-carbo-2'-ethyl-hexyl-1 '-oxy) -1,3,5-triazine (Uvinul®T150) • phenol, 2- (2H-benzotriazol-2-yl) -4-methyl-6 - (2-methyl-3 (1,3,3,3tetramethyl-1 - (trimethylsilyl) oxy) disyloxianyl) propyl) (Mexoryl® XL) • 4.4 '- [(6- [4- (1,1- dimethyl) aminocarbonyl) phenylamino] -1,3,5triazine-2,4-diyl) diimino] -bis- (benzoic acid 2-ethylhexyl ester) (Uvasorb HEB) • 3- (4'-methyl benzylidene) - D, L-camphor (Neo Heliopan® MBC) • 3-benzylidene camphor • 2-ethylhexyl ester of salicylic acid co (Neo Heliopan® OS)
    21/56 • 4-Dimethylaminobenzoic acid 2-ethylhexyl ester (Padimate O) • Hydroxy-4-methoxybenzophenone-5-sulfonic acid and Na salt • 2,2'-methylene-bis- (6- (2H-benzotriazole -2-yl) -4-1,1,3,3tetramethylbutyl) phenol) (Tinosorb® M) • Disodium salt of phenylene bis-benzimidazyl tetrasulfonic acid (Neo Heliopan® AP) • 2,4-bis - [{(4 - (2-ethylhexyloxy) -2-hydroxy} phenyl] -6- (4-methoxyphenyl) -
    1,3,5-triazine (Tinosorb® S) • Polysiloxane benzylidene malonate (Parsol®SLX) • Menthyl anthranilate (Neo Heliopan® MA) • 2- (4-diethylamino-2-hydroxybenzoyl) benzoic acid hexyl ester (Uvinul ® A Plus) • Indanilidene compounds according to DE 100 55 940 (= WO 02/38537).
    [40] Advantageous primary and also secondary sun protection factors are cited in WO 2005 123101 A1. Advantageously, these preparations contain at least one UVA filter and / or at least one UVB filter and / or at least one inorganic pigment. The preparations can be present in this case in various forms such as are conventionally used for sun protection preparations. Thus, they can be in the form of a solution, water-in-oil (W / O) or oil-in-water (O / W) or multiple emulsion, for example, water-in-water (W / O) / W), gel, hydrodispersion, solid stick or aerosol.
    [41] In yet another embodiment, a formulation according to the invention contains a total amount of agents such as sunscreen, that is, especially UV filters and / or inorganic pigments (UV filtering pigments) so that the formulation according to the invention has a light protection factor greater than or equal to
    22/56 (preferably greater than or equal to 5). Such formulations according to the invention are especially suitable for protecting skin and hair.
    F. Secondary sun protection factors [42] In addition to the groups of primary sun protection factors that are mentioned above, secondary antioxidant type sun protection factors can also be used. Secondary antioxidant-type sun protection factors interrupt the photochemical reaction chain that is initiated when UV rays penetrate the skin. Typical examples are amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg, urocanic acid) and their derivatives, such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (for example, anserine), carotinoids, carotenes (for example, alpha-carotene, beta-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, liponic acid and its derivatives (for example, dihydroliponic acid), aurothioglycosis, propylthiouracil and other thiols (for example, thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, alpha-linoleyl, cholesteril and glyceryl esters of these) and their salts, dilaurylthiodipropionate, disetearylthiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (for example, butionin sulfoximines, sulfoximine homocysteine imine, butionine sulfones, penta, hexa and hepta-thionine sulfoximine) in very small compatible doses, in addition to chelators (of metals) (eg alpha hydroxy acids, palmitic acid, phytic acid, lactoferrin), alpha hydroxy acids ( for example, citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and its derivatives, unsaturated fatty acids and their derivatives (for example, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone
    23/56 and ubiquinol and its derivatives, vitamin C and its derivatives (eg ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg vitamin E acetate), vitamin A and derivatives (palmitate vitamin A) and benzoin resin coniferyl benzoate, rutinic acid and its derivatives, glycosyl rutin, ferulic acid, furfurylidene glucitol, carnosine, butyl hydroxytoluene, butyl hydroxyanisole, nordi-hydro-hydroxy acid in resin, nordhydro-hydroxy acid, tri-hydroxy acid, tri-hydroxy acid and its derivatives, mannose and its derivatives, superoxide dismutase, titanium dioxide (for example, dispersions in ethanol), zinc and its derivatives (for example, ZnO, ZnSO 4 ), selenium and its derivatives (for example, selenium methionine), stilbenes and their derivatives (for example, stilbene oxide, trans-stilbene oxide) and derivatives of such active substances suitable for the purposes of the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids).
    [43] Advantageous secondary inorganic pigments for protection against light are metal oxides and finely dispersed metal salts, which are also cited in WO 2005 123101 A1. The total amount of inorganic pigments, especially hydrophobic inorganic micropigments, in the finished cosmetic preparation according to the present invention is advantageously from 0.1 to 30% by weight, preferably from 0.5 to 10.0% by weight, in each case based on the total weight of the preparation.
    [44] UV filters or particulate inorganic pigments are also preferred, which can optionally be hydrophobized, and can be used, such as titanium oxides (TiO 2 ), zinc (ZnO), iron (Fe 2 O 3 ), zirconium (ZrO 2 ), silicon (SiO 2 ), manganese (for example, MnO), aluminum (AI 2 O 3 ), cerium (for example, Ce 2 O 3 ) and / or their mixtures.
    G. Agents active against aging [45] In the context of the invention, agents against aging
    24/56 or biogenics are, for example, antioxidants, matrix metalloproteinase inhibitors (MMPI), skin moisturizing agents, glycosaminoglycan stimulators, anti-inflammatory agents, TRPV1 antagonists and plant extracts.
    [46] (i) Antioxidants. Amino acids (preferably glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (preferably urocanic acid) and their derivatives, peptides, preferably D, L-carnosine, D-carnosine, L-carnosine and their derivatives (preferably anserine), carnitine, creatine, matricin peptides (preferably lysyl-threonyl-threonyl-lysyl-serine) and palmitoylated, carotenoid, carotene pentapeptides (preferably alpha-carotene, beta-carotene, lycopene) and their derivatives, lipoic acid and its derivatives (preferably dihydrolipoic acid), aurothioglycosis, propyl thiouracil and other thiols (preferably thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl , oleyl, gamma-linoleyl, cholesteryl, glyceryl and oligoglyceryl esters thereof) and their salts, dilauryldipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (preferably esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (preferably butionin sulfoximines, homocysteine sulfoximine, butionin sulfones, penta, hexa, heptathionine sulfoximine) in small tolerated doses (eg pmol to pmol / kg), also chelators (of metals ) (preferably alpha-hydroxy fatty acid, palmitic acid, phytic acid, lactoferrin, alpha-hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, tannins, bilirubin, biliverdin, EDTA, EGTA and its derivatives), unsaturated fatty acids and their derivatives (preferably gamma-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and its derivatives, ubiquinol and its derivatives, vitamin C and derivatives ( in
    25/56 preference ascorbyl palmitate, ascorbyl Mg phosphate, ascorbyl acetate, ascorbyl glycoside), tocopherols and derivatives (preferably vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and benzoic resin coniferyl benzoate , rutinic acid and its derivatives, flavonoids and its glycosylated precursors, especially quercetin and its derivatives, preferably alpha-glycosyl rutin, rosmarinic acid, carnosol, carnosolic acid, resveratrol, caffeic acid and its derivatives, synapic acid and its derivatives, ferulic acid and its derivatives, curcuminoids, chlorogenic acid and its derivatives, retinoids, preferably retinyl palmitate, retinol or tretinoin, ursolic acid, levulinic acid, butyl hydroxytoluene, butyl hydroxyanisole, nordi-hydro-hydroxy acid, nordi-hydro-hydroxy acid, trihydroxy, hydroxy and hydroxy and its derivatives, mannose and its derivatives, zinc and its derivatives (preferably ZnO, Z nSO 4 ), selenium and its derivatives (preferably selenium methionine), superoxide dismutase, stilbenes and their derivatives (preferably stilbene oxide, trans-stilbene oxide) and derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides , peptides and lipids) of those active ingredients mentioned that are suitable according to the invention or extracts or plant fractions that have an antioxidant effect, preferably green tea, rooibos, honey bush, grape, rosemary, sage, melissa, thyme, lavender , olive, oats, cocoa, ginkgo, ginseng, licorice, honeysuckle, Sophora, Pueraria, pine, citrus, Phyllanthus emblica or St. John's wort, grape seeds, wheat germ, Phyllanthus emblica, coenzymes, preferably coenzyme Q10, plastoquinone and menaquinone. Preferred antioxidants are selected from the group consisting of vitamin A and derivatives, vitamin C and derivatives, tocopherol and derivatives, preferably tocopheryl acetate, and ubiquinone.
    26/56 [47] (ii) Matrix metalloproteinase (MMPI) inhibitors. Preferred compositions comprise matrix metalloproteinase inhibitors, especially those that inhibit matrix metalloproteinases by collagen enzyme divination, selected from the group consisting of: ursolic acid, retinyl palmitate, propylate, precocenes, 6-hydroxy-7 -methoxy-2,2-dimethyl-1 (2H) -benzopyran, 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H) -benzopyran, benzamidine hydrochloride, cysteine proteinase N-ethylmalemide inhibitors and epsilon-amino-n-caproic acid from serine protease inhibitors: phenylmethylsufonyl fluoride, Colhibin (company: Pentapharm; INCI: hydrolyzed rice protein), Oenotherol (company: Soliance; INCI: propylene glycol , aqua, Oenothera biennis root extract, ellagic acid and elagitanins, for example, pomegranate), phosphoramidone hyquinox, EDTA, galardin, EquiStat (company: Collaborative Group; apple extract, soybean seed extract, isoflavone ursulic acid from soy and pr soy proteins), sage extracts, MDI (company: Atrium; INCI: glycosaminoglycans), Fermiskin (company: Silab / Mawi; INCI: water and Lentinus edodes extract), Actimp 1.9.3 (company: Expanscience / Rahn; INCI: hydrolysed lupine protein), Lipobelle Soyaglycone (company: Mibelle; INCI : alcohol, polysorbate 80, soy lecithin and isoflavones), green tea and black tea extracts and other plant extracts that are listed in WO 02 069992 A1 (see Tables 1-12 in that document, incorporated herein by reference in this patent application ), soy proteins or glycoproteins, hydrolyzed proteins of rice, peas or lupine, plant extracts that inhibit MMPs, preferably extracts of shitake mushrooms, extracts from the leaves of the Rosaceae family, subfamily Rosoideae, and especially the extracts from the aroma leaf ( preferably as described in WO 2005 123101 A1, incorporated herein by reference in this patent application) such as, for example, SymMatrix (company: Symrise, INCI: Maltodextri
    27/56 na, extract from the leaves of Rubus Fruticosus (blackberry)). The preferred active ingredients are selected from the group consisting of retinyl palmitate, ursolic acid, extracted from the leaves of the Rosaceae family, subfamily Rosoideae, genistein and daidzein.
    [48] (III) Skin moisturizing agents. Preferred skin moisturizing agents are selected from the group consisting of alkane diols or alkane triols comprising 3 to 12 carbon atoms, preferably C 3 -Ci 0 -alkane diols and C 3 -Ci 0 -alkane triols. More preferably, skin moisturizing agents are selected from the group consisting of: glycerol, 1,2-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1 , 2-octanodiol and 1,2-decanediol.
    [49] (iv) Glycosaminoglycan stimulators. Preferred compositions comprise substances that stimulate the synthesis of glycosaminoglics, selected from the group consisting of hyaluronic acid and derivatives or salts, Subliskin (Sederma, INCI: Fermented Sinorhizobium Meliloti filtrate, cetyl hydroxyethylcellulose, lecithin), Hyalufix (BASF, INCI: water, butylene glycol, Alpinia galanga leaf extract, xanthan gum, caprylic / capric triglyceride), Stimulhyal (Soliance, INCI: calcium ketogluconate), Syn-Glycan (DSM, INCI: tetradecyl trifluoroacetate, aminobutyryl Valve, hydrochloride, glycine, urea, chloride, glycine, urea magnesium), Kalpariane (Biotech Marine), DC Upregulex (Distinctive Cosmetic Ingredients, INCI: water, butylene glycol, phospholipids, hydrolyzed sericin), glucosamine, N-acetyl glucosamine, retinoids, preferably retinol and vitamin A, Arctium lappa fruit extract , extract of Eriobotrya japonica, Genkwanin, N-methyl-L-serine, (-) - alfabisabolol or synthetic alpha-bisabolol as, for example, example, Dragosantol and Dragosantol 100 from Symrise, oat glucan, Echinacea purpurea extract and hydrolyzed soy protein. The preferred active ingredients are selected from the group consisting of hyaluronic acid
    28/56 co and derivatives or salts, retinol and derivatives, (-) - alpha-bisabolol or synthetic alfabisabolol such as, for example, Dragosantol and Dragosantol 100 by Symrise, oat glucan, Echinacea purpurea extract, fermented Sinorhizobium Meliloti filtrate, calcium ketogluconate, Alpinia galanga leaf extract and tetradecyl aminobutyrylvalylaminobutyric-urea trifluoroacetate.
    [50] (v) Anti-inflammatory agents. The compositions may also contain anti-inflammatory and / or ingredients that improve redness and / or itching, especially steroidal substances of the corticosteroid type, selected from the group consisting of hydrocortisone, dexamethasone, dexamethasone phosphate, methyl prednisolone or cortisone, which they are advantageously used as anti-inflammatory active ingredients or active ingredients to relieve redness and itching, the list of which can be extended by the addition of other non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs can also be used. Examples that can be cited in this case are oxicans such as piroxicam or tenoxicam; salicylates such as aspirin, Disalcid, Solprin or Fendosal; acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; phenomena such as mefenamic, meclophenamic, flufenamic or niflumic; propionic acid derivatives like ibuprofen, naproxen, benoxaprofen or pyrazoles like phenylbutazone, oxyphenylbutazone, febrazone or azapropazone. Anthranilic acid derivatives, especially avenanthramides described in WO 2004 047833 A1, are preferred ingredients against itching in a composition according to the present invention.
    [51] Natural anti-inflammatory mixtures of substances or mixtures of substances that relieve redness and / or itching are also useful, especially extracts or fractions of chamomile, Aloe vera, of the species Commiphora, of the species Rubia, of willow, of grass
    29/56 willow, oats, marigold, arnica, St. John's wort, honey bush, rosemary, Passiflora incarnata, witch hazel, ginger or Echinacea ', preferably selected from the group consisting of extracts or fractions of chamomile, Aloe vera, oats, marigold, arnica, honey bush, rosemary, witch hazel, ginger or Echinacea, and / or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glycoside, gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradises, natural or naturally occuring natural or naturally occurring avenanthramides, preferably tranilast, avenanthramide A, avenanthramide B, avenanthramide C, unnatural or non-naturally occurring avenanthramides, preferably dihydroavenanthramide D, dihydroavenanthramide E, avenanthramide D, avenanthramide E, avenanthramide F, avenanthramide F, boswellic acid, phytosterols, glycyrrhizin, glabridine and licochalcona A; preferably selected from the group consisting of alpha-bisabolol, natural avenanthramides, unnatural avenanthramides, preferably dihydroavenanthramide D (as described in WO 2004 047833 A1), boswellic acid, phytosterols, glycyrrhizin and lycochalcone A, and / or allantoin, panthenol, lanolin, (pseudo) ceramides [referably Ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glyceryl methoxypropyl myristamide, N- (1-hexadecanoyl) -4-hydroxy-L-proline ester, hydroxyethyl palmityl oxyhydro palmityl oxide ], glycosphingolipids, phytosterols, chitosan, mannose, lactose and β-glucans, especially oat 1,3-1,4-3-glucan.
    [52] (vi) TRPV1 antagonists. Suitable compounds that reduce the hypersensitivity of cutaneous nerves based on their action as TRPV1 antagonists, include, for example, trans-4-tert-butyl cyclohexanol as described in WO 2009 087242 A1, or indirect TRPV1 modulators by activation μ receptor, for example, acetyl tetrapeptide-15, are preferred.
    30/56 [53] (vii) Botanical extracts. The compositions may also contain various plant extracts, such as, for example, Ginkgo biloba extracts, Oleacea europensis, Glyzyrrhiza glabra, Vaccinium myrtillus, Trifolium pratense, Litchi sinensis, Vitis, vinifera, Brassica oleracea, Punica granatum, Petroselinium crispum, Centella asiap , Passiflora incarnata, Medicago sativa, Melissa officinalis, Valeriana officinalis, Castanea sativa, Salix alba and Hapagophytum procumbens.
    H. Cooling agents [54] The compositions may also contain one or more substances with a physiological cooling effect (cooling agents), which are preferably selected from the following list: menthol and menthol derivatives (for example, L-menthol, D- menthol, racemic menthol, isomentol, neoisomentol, neomentol) menthyl ethers (eg ((Imentoxy) -1,2-propanediol, (l-menthoxy) -2-methyl-1,2-propanediol, l-mentylmethyl ether), menthol esters (for example, menthol formate, menthyl acetate, menthol isobutyrate, menthyl lactates, L-mentyl-L-lactate, L-mentyl-D-lactate, menthyl- (2-methoxy) acetate, menthyl- (2-methoxyethoxy) acetate , menthylpyroglutamate), menthylcarbonates (for example, menthylpropylene glycolcarbonate, menthyl ethylene glycolcarbonate, menthyl glycerolcarbonate or mixtures thereof), menthol semesters with a dicarboxylic acid or its derivatives (e.g. O- N- (dimethyl) amide -mentyl succinic, amide ester of O-menthyl succinic acid), amides of mentanocarboxylic acid (in this case, preferably mentanocarboxylic acid-N-ethylamide [WS3] or N- (mentanocarbonyl) glycine ester [WS5], as described in US 4 150 052, mentanocarboxylic acid-N- (4-cyanophenyl) amide or mentanocarboxylic acid-N- (4-cyanomethylphenyl) amide as described in WO 2005 049553 A1, methanecarboxylic acid-N- (alkoxyalkyl) amide, menthol and menthol derivatives (by example, L-mentone glycerol ketal), derivatives of 2,3-dimethyl-2- (2
    31/56 propyl) -butyric (for example, 2,3-dimethyl-2- (2-propyl) -butyric-Nmethylamide [WS23]), isopulegol or its esters (l - (-) - isopulegol, l- ( -) isopulegolacetate), derivatives of menthane (for example, p-menthane3,8-diol), cubebol or synthetic or natural mixtures, containing cubebol, pyrrolidone derivatives of cycloalkyldione derivatives (for example, 3-methyl-2 (1-pyrrolidinyl) - 2-cyclopentene-1-one) or tetrahydropyrimidine-2one (for example, icylin or related compounds, as described in WO 2004/026840), other carboxamides (for example, N- (2 (pyridin-2-yl) ethyl ) -3-p-mentanecarboxamide or related compounds), (1R, 2S, 5R) -N- (4-methoxyphenyl) -5-methyl-2- (1-isopropyl) cyclohexanecarboxamide [WS12], oxamates (preferably those described in EP 2033688 A2).
    I. Antimicrobial agents [55] Suitable antimicrobial agents are, in principle, all substances effective against Gram-positive bacteria, such as, for example, 4-hydroxybenzoic acid and its salts and esters, N- (4-chlorophenyl) -N'- (3,4-dichlorophenyl) urea, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), 4-chloro-3,5-dimethyl-phenol, 2,2'-methylenebis (6-bromo4- chlorophenol), 3-methyl-4- (1-methylethyl) phenol, 2-benzyl-4-chloro-phenol, 3- (4-chlorophenoxy) -1,2-propanediol, 3-iodo-2-propynyl butylcarbamate, chlorhexidine, 3,4,4'-trichlorocarbanilide (TTC), antibacterial fragrances, thymol, thyme oil, eugenol, clove oil, menthol, mint oil, farnesol, phenoxyethanol, glycerol monocaprate, glycerol monocaprilate, glycerol monolaurate (GML ), diglycerol monocaprate (DMC), N-alkylamides of salicylic acid, such as, for example, noctilsalicylamide or n-decylsalicylamide.
    J. Enzyme inhibitors [56] Suitable enzyme inhibitors are, for example, esterase inhibitors. These are preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, tributyl citrate and, speci
    32/56, triethyl citrate (Hydagen CAT). The substances inhibit the activity of enzymes, thus reducing the formation of odor. Other substances that are suitable esterase inhibitors are sterol sulfates or phosphates, such as, for example, lanosterol sulfate or phosphate, cholesterol, campesterol, stigmasterol and sitosterol, dicarboxylic acids and esters thereof, such as glutaric acid, glutarate monoethyl, diethyl glutarate, adipic acid, monoethyl adipate, diethyl adipate, malonic acid and diethyl malonate, hydroxycarboxylic acids and esters thereof, such as, for example, citric acid, malic acid, tartaric acid or tartarate diethyl, and zinc glycinate.
    K. Odor absorbers and active antiperspirant agents [57] Suitable odor absorbers are substances that are capable of absorbing and largely retaining odor-forming compounds. These agents reduce the partial pressure of the individual components, thus also reducing their rate of diffusion. It is important that, in this process, perfumes need not be compromised. Odor absorbers are not effective against bacteria. As a main constituent, they comprise a zinc salt complex of ricinoleic acid or specific fragrances to a large extent with a neutral odor that are known to the person skilled in the art as fixatives, such as, for example, extracts from Labdanum (labdanum) or Styrax (benzoin) or certain derivatives of abietic acid. Odor-masking agents are fragrances or perfume oils, which, in addition to their function as odor-masking agents, provide deodorants with their respective fragrance note. The perfume oils that can be mentioned are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts from flowers, stems and leaves, fruits, fruit peels, roots, wood
    33/56 ras, herbs and grasses, tips and branches, and resins and balms. Animal products, such as civet and castoro, are also suitable. Typical synthetic fragrance compounds are ester, ether, aldehyde, ketone, alcohol and hydrocarbon products. Ester-type fragrance compounds are, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexylpropionate, styryl propionate and benzyl salicylate. Ethers include, for example, ethyl benzyl ether, and aldehydes include, for example, linear alkanes with 8 to 18 carbon atoms, citral, citronelal, citronelyloxyacetaldehyde, Cyclamen aldehyde, hydroxycitronelal, lilial and bourgeonal, ketones include, for example For example, ionones and methyl cedril ketone, alcohols include anethole, citronelol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, and hydrocarbons mainly include terpenes and balms. Preference is, however, given to using mixtures of different fragrances that together produce a pleasant fragrance note. Essential oils of relatively low volatility, which are mainly used as aroma components, are also suitable as perfume oils, for example, sage oil, chamomile oil, clove oil, melissa oil, peppermint oil, cinnamon leaf oil, linden flower oil, juniper berry oil, vetiver oil, frankincense oil, galbanum oil, labdanum oil and lavandin oil. Preference is given to using bergamot oil, dihydromyrcenol, lilial, liral, citronelol, phenylethyl alcohol, α-hexylcinamaldehyde, geraniol, benzylacetone, Cyclamen aldehyde, linalool, strong Boisambrene, Ambroxan, indole, hedione, Sandelice, lemon oil , tangerine oil, orange oil, allyl amyl glycolate, cyclovertal, lavandin oil, clear sage oil, β-damask, Bourbon geranium oil, cyclohexyl salicylate, Vertofix coeur, iso-E-super, Fixolide NP, evernil iraldein ga
    34/56 ma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilat, irotil and floramat, alone or in mixtures.
    [58] The astringent antiperspirant active ingredients are primarily aluminum, zirconium or zinc salts. Such suitable anti-hydrotic active ingredients are, for example, aluminum chloride, aluminum hydrochloride, aluminum dihydrochloride, aluminum sesquichlorohydrate and complex compounds thereof, for example, with 1,2-propylene glycol, aluminum hydroxyalantoinate, aluminum chloride tartrate , aluminum and zirconium pentachlorhydrate and complex compounds of these, for example, with amino acids, such as glycine.
    L. Film makers and anti-dandruff agents [59] Standard film makers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, acrylic acid series polymers, quaternary cellulosic derivatives, collagen, hyaluronic acid and its salts and similar compounds.
    [60] Suitable anti-dandruff agents are Pirocton Olamin (monoethanolamine salt of 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2- (1H) pyridinone), Baypival® (Climbazole), Ketoconazole ® (4-acetyl-1- {4- [2- (2,4dichlorophenyl) r-2- (1 H-imidazol-1-ylmethyl) -1,3-dioxylan-c-4-yl-methoxyphenyl} piperazine, ketoconazole, elubiol, selenium disulfide, colloidal sulfur, sorbitan-sulfur polyethylene glycol monooleate, ricinol-sulfur polyethoxylate, sulfur tar distillate, salicylic acid (or in combination with hexachlorophene), undecylenic acid, sulfosuccinate Na salt Lamepon® UD (protein condensate / undecylenic acid), zinc pyrithione, aluminum pyrithione and magnesium pyrithione / magnesium dipyrithione sulfate.
    M. Carriers and hydrotropes [61] The preferred carrier materials for cosmetics are solids or liquids at 25 Ό and 1013 mbar (0.1 MPa) (including substance
    35/56 highly viscous) such as, for example, glycerol, 1,2propylene glycol, 1,2-butylene glycol, 1,3-propylene glycol, 1,3-butylene glycol, ethanol, water and mixtures of two or more of said liquid carrier materials with water. Optionally, these preparations according to the invention can be produced using preservatives or solubilizers. Other preferred liquid carrier substances, which can be a component of a preparation according to the invention, are selected from the group consisting of oils such as vegetable oil, neutral oil and mineral oil.
    [62] Preferred solid carrier materials, which can be a component of a preparation according to the invention, are hydrocolloids, such as starches, degraded starches, chemically or physically modified starches, dextrins, maltodextrins (powder) (preferably with a value) dextrose equivalent of 5 to 25, preferably 10 - 20), lactose, silicon dioxide, glucose, modified celluloses, gum arabic, ghatti gum, tragacanth gum, karaya, carrageenan, pullulan, curdlan, xanthan gum, gelanine gum, flour guar, carob seed flour, alginates, agar, pectin and inulin and mixtures of two or more of these solids, especially maltodextrins (preferably with an equivalent dextrose value of 15 - 20), lactose, silicon dioxide and / or glucose .
    [63] Additionally, hydrotopes, for example, ethanol, isopropyl alcohol or polyols, can be used to improve the behavior of flour. Suitable polyols preferably contain 2 to 15 carbon atoms and at least two hydroxyl groups. Polyols can contain other functional groups, most especially amino groups, or they can be modified with nitrogen. Typical examples are:
    • Glycerol;
    • alkylene glycols such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols
    36/56 with an average molecular weight of 100 to 1000 Dalton;
    • technical mixtures of oligoglycerol with a self-condensation degree of 1.5 to 10, such as, for example, technical mixtures of diglycerol with a content of diglycerol of 40 to 50% by weight;
    • methylol compounds such as, especially, trimethylol ethane, trimethylol propane, trimethylol butane, pentaerythritol and dipentaerythritol;
    • lower alkyl glycosides, especially those containing 1 to 8 carbon atoms in the alkyl group, for example, methyl and butyl glycosides;
    • sugar alcohols containing 5 to 12 carbon atoms, for example, sorbitol or mannitol, • sugars containing 5 to 12 carbon atoms, for example, glucose or sucrose;
    • amino sugars, for example, glycamine;
    • dialcoolamines, such as diethanolamine or 2-aminopropane1,3-diol.
    N. Preservatives [64] Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid and the other classes of compounds listed in Appendix 6, Parts A and B of the Kosmetikverordnung (“Cosmetics Directive”) .
    O. Perfume oils and fragrances [65] Suitable perfume oils are mixtures of natural and synthetic perfumes. Natural perfumes include inflorescence extracts (lily, lavender, rose, jasmin, Neroli, Ylang-Ylang), stems and leaves (geranium, Patchouli, Petitgrain), fruits (anise, coriander, cumin, juniper), fruit peel ( bergamot, lemon, orange), roots (nutmeg, angelica, celery, cardamom, costo, iris, calamus), woods (pine wood, sandalwood, guaiac wood, cedar wood, rosewood), herbs and grasses (tarragon, grass
    37/56 lemon, sage, thyme), tips and branches (spruce, fir, pine, dwarf pine), resins and balms (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). It is also possible to use raw materials derived from animals, for example, civet and beaver. Typical synthetic perfume compounds are ester, ether, aldehyde, ketone, alcohol and hydrocarbon products. Examples of ester-type perfume compounds are benzyl acetate, phenoxyethyl isobutyrate, p-tert-butyl cyclohexylacetate, linalyl acetate, dimethyl benzyl carbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenyl glycinate, cyclohexyl allyl propionate, styryl propionate and benzyl salicylate. Ethers include, for example, ethyl benzyl ether, while aldehydes include, for example, linear alkanes containing 8 to 18 carbon atoms, citral, citronelal, citronelyloxyacetaldehyde, Cylamen aldehyde, hydroxycitronelal, lilial and bourgeonal. Examples of suitable ketones are ionones, α-isomethionone and methyl cedryl ketone. Suitable alcohols are anethole, citronelol, eugenol, isoeugenol, geraniol, linalolol, phenylethyl alcohol and terpineol. Hydrocarbons mainly include terpenes and balms. However, it is preferred to use mixtures of different perfume compounds, which together produce a pleasant perfume. Other suitable perfume oils are essential oils of relatively low volatility which are used primarily as aroma components. Examples are salvia oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, lemon flower oil, juniper berry oil, vetiver oil, olibanum oil, galbanum, labdanum oil and lavendin oil. The following are preferably used either individually or in the form of mixtures: bergamot oil, dihydromyrcenol, lilial, liral, citronellol, phenylethyl alcohol, hexylcinamaldehyde, geraniol, benzyl acetone, Cyclamen aldehyde, linalolol, Boisambrene Forte, Ambroxan, indole, hideous,
    38/56
    Sandelice, citrus oil, tangerine oil, orange oil, allyl amyl glycolate, cyclovertal, lavendin oil, clear sage oil, Bourbon geranium oil, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernil, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romillat, irotil and floramat.
    P. Dyes [66] Suitable dyes are any of the substances suitable and approved for cosmetic purposes as listed, for example, in the publication “Kosmetische Fãrbemitter by Farbstoffkommission der Deutschen Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984, pages 81 to 106. The examples include cochineal red A (Cl 16255), blue blue V (Cl 42051), indigotine (Cl 73015), chlorophyllin (Cl 75810), quinoline yellow (Cl 47005), titanium dioxide (Cl 77891), indanthrene blue RS (Cl 69800) and Madder Lago (Cl 58000). Luminol can also be present with a luminescent dye. Advantageous colored pigments are, for example, titanium dioxide, mica, iron oxides (for example, Fe 2 O 3 Fe 3 O 4 , FeO (OH)) and / or tin oxide. Advantageous dyes are, for example, carmine, Berlin blue, green chromium oxide, ultramarine blue and / or violet manganese.
    [67] The compositions according to the present invention are selected from products for the treatment, protection, care and cleaning of the skin and / or hair or as a makeup product, preferably as a product without rinsing ( leave-on) (meaning that one or more compounds of Formula (I) remain on the skin and / or hair for a longer period of time, when compared to rinse-off products, so that their action moisturizing and / or against aging and / or promoting wound healing is more pronounced).
    39/56 [68] The formulations according to the invention are preferably in the form of an emulsion, for example, emulsion W / O (water in oil), O / W (oil in water), W / O / W (water in oil in water), O / W / O (oil in water in oil), PIT emulsion, Pickering emulsion, emulsion with low oil content, micro or nanoemulsion, of solution, for example, in oil (fatty oils or esters of fatty acids, especially C 2 -C 30 esters of C 6 -C 3 2 fatty acids) or silicone oil, dispersion, suspension, cream, lotion or milk, depending on the production method and ingredients, gel (including hydrogel, hydrodispersion gel, oleogel), spray (for example, pump spray or spray with propellant) or foam or impregnating solution for cosmetic wipes, detergent, for example, soap, synthetic detergent, washing liquid, prepared for bathing in shower or bath, bath products (capsule, oil, tablet, salts, bath salts, soap, etc.), pr effervescent, skin care product such as an emulsion (as described above), ointment, paste, gel (as described above), oil, balm, serum, powder (for example, face powder, body powder ), a mask, pencil, stick, roller, pump, aerosol (foaming, non-foaming or after foam), a deodorant and / or antiperspirant, mouthwash and mouthwash, a foot care product (including keratolytic, deodorant), an insect repellent, a sunscreen, a preparation after sun exposure, a shaving product, an aftershave balm, pre and aftershave lotion, a hair removal agent, a hair care product such as shampoo (including 2 in 1 shampoo, anti-dandruff shampoo, baby shampoo, scalp health shampoo, concentrated shampoo), conditioner, hair tonic, hair water, hair rinse liquid, hair cream, ointment, lotion to stay hairstyles, hairspray, hair styling aid
    40/56 creating hairstyles (for example, gel or wax), hair softening agent (agent to untangle the hair, relaxing), hair dye such as, for example, dye for the temporary direct dyeing of hair, semi-permanent hair dye, permanent hair dye, hair conditioner, hair mousse, eye care product, makeup, makeup remover or baby product.
    [69] The formulations according to the invention are especially preferably in the form of an emulsion, especially in the form of a W / O, O / W, W / O / W, O / W / O emulsion, PIT emulsion, Pickering emulsion , emulsion with a low oil content, micro or nanoemulsion, gel (including hydrogel, hydrodispersion gel, oleogel), solution, for example, in oil (fatty oils or fatty acid esters, especially C 2 -C esters 30 of C 6 -C 32 fatty acids) or silicone oil, or spray oil (eg, pump spray or propellant spray).
    [70] Auxiliary substances and additives may be included in amounts of 5 to 99% by weight (by weight), preferably 10 to 80% by weight, based on the total weight of the formulation. The quantities of auxiliary agents and cosmetic or dermatological and perfume additives, to be used in each case, can be easily determined by the technician in the subject by simple trial and error, depending on the nature of the particular product.
    [71] The preparations can also contain water in an amount of up to 99% by weight, preferably 5 to 80% by weight, based on the total weight of the preparation.
    Industrial application [72] In a preferred embodiment, the compositions according to the present invention comprise the components in the following amounts:
    41/56 (a) approximately 0.1 to approximately 5, preferably approximately 0.3 to approximately 3 and more preferably close to 0.5% by weight to close to 2.5% by weight of menthol ketals of Formula ( I);
    (b) approximately 99.9 to approximately 50, preferably approximately 95 to approximately 65 and more preferably approximately 80 to approximately 70% by weight of body oils and / or waxes;
    (c) 0 to about 25, preferably about 1 to about 15 and more preferably about 4 to about 8% by weight of emulsifiers;
    (d) 0 to about 25, preferably about 0.5 to about 10 and more preferably close to 1 to about 5% by weight of active ingredients;
    with the proviso that the added amounts - optionally together with water and additional ingredients - total 100% by weight [73] The compositions of the invention may contain water or are essentially free of water. Essentially free means that the amount of water is less than 2, preferably less than 1 and more preferably less than 0.5% by weight, calculated on the basis of the final product.
    [74] The compositions according to the invention can represent o / w or w / o emulsion or multiple o / w / o or w / o / w. In addition, they can be used as intermediates or a final product, for example, in the form of lotion, cream or stick.
    [75] Two other embodiments of the present invention concern the use of menthol ketals according to Formula (I) as stabilizers for cosmetic compositions and as additives capable of improving the sensory profile of cosmetic compositions.
    42/56
    Examples
    Examples 1 to 3, Comparative examples C1 to C3 [76] O / W emulsions were prepared by heating a lipid phase A and a separate aqueous phase B to approximately 80 “0. Then the aqueous phase B was added to the lipid phase A and mixed in an Ultra-Turrax for 2 minutes at 5,000 rpm. The emulsion thus obtained was allowed to cool for 10 minutes, using a rotary shaker at 150 rpm. Finally, the pH value was adjusted to approximately 8.0 by adding aqueous sodium hydroxide solution. The stability of the emulsions was determined using an analytical centrifuge of the type LUMisizer® (L.U.M. GmbH) that measures the change in transmission over time. The instability index is defined between 0 (very stable) and 1 (complete separation). The experiments were conducted at 25 Ό with a speed of 2,500 rpm for 1.25 h, corresponding to the storage time of approximately 1 month. The composition of the emulsions and the stability results are given in Table 1. Examples 1 to 3 are according to the invention, Examples C1 to C3 are for comparison.
    [77] Table 1. O / W emulsions comprising Emulsiphos®
    Phase Compound C1 C2 C3 1 2 3 THE Potassium cetyl phosphate (e) Hydrogenated palm glyceridesEmulsiphos® PN 677660 2.0 2.0 2.0 2.0 2.0 2.0 Lanette® O cetearyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Capricious glycerides / caprylic Myritol®312 10.0 - - 10.0 - - Cetearyl ethylhexanoate - 10.0 - - 10.0 -
    43/56
    Phase Compound C1 C2 C3 1 2 3PCL Liquid 100 Soy oil - - 10.0 - - 10.0Mentone Glycerin Acetal (FEMA 3807) Frescolat® MGA - - - 2.0 2.0 2.0DimethiconeAbil® 350 0.1 0.1 0.1 0.1 0.1 0.1 B Glycerol 1.0 1.0 1.0 1.0 1.0 1.0 Water Added to 100 instability index 0.35 0.47 0.36 0.08 0.38 0.19
    [78] The examples and comparative examples clearly demonstrate that adding Mentone Glycerin Acetal (FEMA 3807) to the emulsions leads to less separation and improves the stability of the emulsion.
    Example 4 to 6, Comparative Examples C4 to C6 [79] O / W emulsions were prepared according to the procedure explained for Examples 1 to 3 with the only exception that the pH value was adjusted to approximately 9.1. The stability of the emulsions was again determined using an analytical centrifuge of the LUMisizer® type (L.U.M. GmbH). The composition of the emulsions and the stability results are provided in Table 2. The
    Examples 4 to 6 are according to the invention, Examples C4 to C6 are for comparison.
    [80] Table 2. O / W emulsions comprising Dracorin®
    Phase Compound C4 C5 C6 4 5 6Glyceryl stearate (e)PEG-100 stearateDracorin® 100 SEP 3.5 3.5 3.5 3.5 3.5 3.5 THE Lanette® O cetearyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5Capsic glycerides 10.0 - - 10.0 - -
    44/56
    Phase Compound C4 C5 C6 4 5 6cos / caprylicMyritol®312 Cetearyl ethylhexanoatePCL Liquid 100 - 10.0 - - 10.0 -Soy oil - - 10.0 - - 10.0Mentone Glycerin Acetal (FEMA 3807) Frescolat® MGA - - - 2.0 2.0 2.0DimethiconeAbil® 350 0.1 0.1 0.1 0.1 0.1 0.1 B Glycerol 1.0 1.0 1.0 1.0 1.0 1.0 Water Added to 100 instability index 0.09 0.22 0.37 0.02 0.12 0.11
    [81] The second set of examples and comparative examples also clearly demonstrates that adding Mentone Glycerin Acetal (FEMA 3807) to emulsions leads to less separation and improves emulsion stability.
    Examples 7 to 9, Comparative Examples C7 to C9 [82] O / W emulsions were prepared according to the procedure explained for Examples 1 to 3. The particle size distribution of the o / w emulsions was measured using a Mastersizer Micro (Malvern) using the laser diffraction principle.
    [83] The emulsion compositions are provided in Table 3 and the results in Table 4 and Figures 1, 2 and 3. Examples 7 to 8 are according to the invention, Examples C7 to C9 are for comparison.
    [84] Table 3. O / W emulsions comprising Emulsiphos®
    Phase Compound C7 C8 C9 7 8 9 THE Potassium cetyl phosphate (e) Hydrogenated palm glycerides 2.0 2.0 2.0 2.0 2.0 2.0
    45/56
    Emulsiphos® PN 677660 Lanette® 0 cetearyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Capricious glycerides / caprylic Myritol® 312 10.0 - - 10.0 - - Cetearyl ethylhexanoatePCL Liquid 100 - 10.0 - - 10.0 - Soy oil - - 10.0 - - 10.0 Mentone Glycerin Acetal (FEMA 3807) Frescolat® MGA - - - 2.0 2.0 2.0 Dimethicone Abil® 350 0.1 0.1 0.1 0.1 0.1 0.1 B Glycerol 1.0 1.0 1.0 1.0 1.0 1.0 Water Added to 100
    [85] Table 4. Particle size distribution (all values in pm)
    Particle size C7 7 C8 8 C9 9 D (v, 0.1) = 10% 3.97 2.04 8.48 1.60 2.37 1.58 D (v, 0.5) = 50% 23.29 10.46 44.15 7.53 14.76 9.32 D (v, 0.9) = 90% 89.13 65.85 103.40 19.40 36.53 21.21
    [86] The “v” indicator refers to a particle size distribution based on volume; all values were extracted from the total distribution Q r . For example, the value 3.97 for C7 means that 10% of the particles show a particle size less than 3.97 pm and so on.
    [87] As you can see, the addition of Mentone Glycerin Acetal (FEMA 3807) shifts the maximum average particle size to smaller values and leads to more finely divided emulsions.
    Example 10, Comparative example C10
    46/56 [88] An emulsion (with a non-perfumed base) was formulated with and without 2.0% by weight of Mentone Glycerin Acetal (FEMA 3807). Then, 0.5 of the two products were placed on a paper filter in a Petri dish and inserted in a Sniffer bag filled with air. Before evaluation by a panel, the odor of an emulsion (fragrance) was introduced into the Sniffer bag. The panel (16 experienced experts) evaluated both samples for perfume intensity and bad odor on a scale from 1 = odorless to 9 = very strong. The reference intensity is defined as 3. The results are reflected in Table 5 and show the arithmetic means of the tests. Example 10 is according to the invention, Example C10 is for comparison.
    [89] Table 6. Masking of bad odor
    Example Product Average perfume intensity Average intensity of bad odor Control Reference 1.00 3.00 C10 Sample without Mentone Glycerin Acetal (FEMA 3807) 1.20 2.25 10 Sample with Mentone Glycerin Acetal (FEMA 3807) 2.67 1.80
    [90] The addition of Mentona Glycerin Acetal (FEMA 3807) to the product increases the intensity of the perfume and reduces the bad odor. Menthol Glycerin Acetal can be used to mask the bad odor of an emulsion.
    Example 11, Comparative example C11 [91] An antiperspirant stick (APP) was formulated with and without Mentone Glycerin Acetal (FEMA 3807), mixing a lipid with an alcoholic phase. The performance of both products was determined with respect to abrasion on the skin and the appearance of the stick that
    47/56 shout. The composition of the sticks and the results are provided in Table 6 and in Figures 4 and 5.
    [92] Table 7. Performance of APP sticks
    Phase Compound C11 11 THE Glyceryl stearate (e) PEG-100 stearateDracorin® 100 SEP 1.0 1.0 Cyclopentasiloxane 52.7 50.7 PEG-150 Polyglycol 6000 S 3.0 3.0 Stearyl alcoholLanette® 18 20.0 20.0 Locron® P aluminum hydrochloride 20.0 20.0 Baby powder 1.0 1.0 SilicaAerosil® 200 1.5 1.5 B Dimethyl phenylpropanol (e) pentylene glycol 0.5 0.5 Mentone Glycerin Acetal (FE-MA 3807)Frescolat® MGA - 2.0 Water Added to 100 Abrasion on the skin Opaque, off-white Smooth, less opaque, creamy Appearance of the broken bat Amorphous Crystalline
    Example 12, Comparative example C12 [93] Two emulsions were formulated with and without 2% Mentone Glycerin Acetal (FEMA 3807). The sensory analysis of both products was carried out during the same session in a room equipped with 12 booths (with monitoring of temperature and humidity). The performance of both products was determined with respect to
    48/56 descriptors. The composition of the emulsions and the results are provided in Tables 7 and 8.
    [94] Table 7. Composition of emulsions
    Phase Compound C12 12 THE Potassium cetyl phosphate, hydrogenated palm glyceridesEmulsiphos® 677660 2 2 Cetearyl alcoholLanette® 0 3 3 Ethylhexyl isononanoateDragoxat® 89 7 7 Caprylic triglyceride / capric neutral oil 5 5 Sodium hydroxyethylacrylate / acryloyldimethyl taurate copolymer (e) Polyisobutene (e) Sepiplus® S coconut PEG-7 trimethylolpropane ether 0.4 - B Phenoxyethanol (e) Decylene glycol (e) 1,2HexanediolSymOcide® PS 1 0.4 AquaWater 81.2 79.2 Keltrol® CG-SFT xanthan gum 0.4 0.4 Ç Mentone Glycerin Acetal (FEMA 3807) Frescolat® MGA - 2
    [95] Table 8: Student test with paired products 12 / C12
    Keywords 12 C12 Meaningfulness (%) Opaque 8.42-1.91 8.10-1.83 17.63 White 9.57-0.81 9.76 - 043 16.85 Bright 9.33-0.91 9.09 - 0.99 28.76 Fluid 6.19-1.96 5.90-2.11 23.24
    49/56
    Keywords 12 C12 Meaningfulness (%) High adhesion 2.42 - 2.06 1.85-1.79 2.64 Slippery 8.33 ± 2.06 8.76 ± 0.94 0.95 Fresh 5.52 ± 2.56 5.80 ± 2.13 44.6 Bleaching 3.42 ± 2.44 4.14 ± 2.97 4.55 Spreadable 8.33 ± 1.15 8.19 ± 1.24 45.38 Greasy 4.57 ± 2.37 6.04 ± 1.93 1.08 Sticky 0.42 ± 0.59 1.04 ± 1.43 3.68 Soft 7.14 ± 1.49 7.33 ± 1.62 70.51 Absorption 8.14 ± 1.76 8.19 ± 1.80 88.04 Film former 0.23 ± 0.88 0.14 ± 0.47 64.96
    [96] The comparison between the two products shows significant differences: the product according to the invention leads to a significant reduction in the descriptors "Greasy", "Sticky", "Slippery" and "Whitening" while increasing "High adherence".
    Example 13, Comparative example C13 [97] A sunscreen was formulated with and without 1% Mentone Glycerin Acetal (FEMA 3807). The sensory analysis of both products was performed during the same session in a room equipped with 12 booths (with monitoring of temperature and humidity). The performance of both products was determined with respect to 14 descriptors. The composition of the emulsions and the results are provided in Tables 9 and 10.
    [98] Table 9. Composition of emulsions
    Phase Compound C12 12Potassium cetyl phosphate (e) Hydrogenated palm glyceridesEmulsiphos® 2 2 THE Cutina® CP cetyl palmitate 1 1Butyl methoxydibenzoylmethane 3 3
    50/56
    Phase Compound C12 12Neo Heliopan® 357 Ethylhexyl salicylateNeo Heliopan® OS 5 5 OctocyleneNeo Heliopan® 303 8 8 HomosalateNeo Heliopan® HMS 5 5 Benzylidene dimethoxydimethylin danonaSymHelios® 1031 0.5 0.5 Ethylhexyl isononanoateDragoxat® 89 2 2 Silcare® Dimethicone Stearyl 1 1 Methicone CaprilylSilsoft® 034 2 2 EDTA® BD disodium EDTA 0.1 0.1 Tocopheryl acetateCopherol® 1250 0.5 0.5 Keltrol® CG-T xanthan gum 0.2 0.2 Cross polymer of acrylates / C 10-30 alkyl acrylateCarbopol® Ultrez 21 0.3 0.3 B Water 46.25 45.25 Phenylbenzimidazole sulfonic acidNeo Heliopan®, neutralized with bioactive L-arginine 12 12 Glycerin 3 3 Arginine Bioactive L-Arginine 0.8 0.8 Ç Phenoxyethanol (e) Decylene glycol (e) 1,2-Hexanediol SymOcide® PS 1.25 1.25
    51/56
    Phase Compound C12 12 D BisabololDragosantol® 100 0.1 0.1 Denatured alcohol 3 3 Mentone Glycerin Acetate Frescolat® MGA - 1 AND Polyamide-5Orgasol® Caresse 1 1 Water, Glycerin (e) Beta-Glucan (e) 1,2Hexanediol (e) Caprylyl glycol SymGlucan® 2 2
    [99] Table 10. Student test with paired products 13 / C13 (Continued)
    Keywords 13 C13 Meaningfulness (%) Opaque 8.75-1.99 8.85-1.98 16.88 White 2.00 - 2.05 2.34-2.10 7.30 Bright 8.85-1.18 8.80-1.10 66.68 Fluid 8.00-1.52 7.80-1.42 16.88 High adhesion 1.95-1.63 1.90-1.65 77.20 Slippery 8.25 - 2.09 8.05-2.13 33.22 Fresh 5.70 - 2.34 5.60-2.18 72.53 Bleaching 2.80-1.85 3.05 - 2.06 35.15 Spreadable 8.10-1.41 8.05-1.50 74.87 Greasy 4.00 - 2.86 4.85-3.18 4.76 Sticky 2.65-1.98 2.60 - 2.08 84.76 Soft 5.30-2.17 5.45-2.16 50.59 Absorption 6.60 - 2.92 6.20-3.17 9.05 Film former 1.75-2.33 1.80-2.62 85.33
    [100] The comparison between the two products shows significant differences: the product according to the invention leads to a significant reduction in the descriptor "Fatty". This means that the product of
    52/56 invention reduces the greasy feeling of lotions for sun care.
    [101] In Tables 11 and 12 below, formulation examples are presented for various cosmetic compositions.
    [102] Table 11. Examples of cosmetic compositions (water, preservatives added to 100% by weight)
    Composition (INCI) THE B ç D AND F G H n Texapon® NSO Laureth sodium sulfate - 30.0 30.0 - 25.0 - - - - - Plantacare® 818 Coconut glycosides - 10.0 - - 20.0 - - - - - Plantacare® PS 10 Texapon® NSO Laureth sodium sulfate (e) Coconut glycosides 22.0 - 5.0 22.0 - - - - - - Dehyton® PK 45 Cocamidopropyl betaine 15.0 10.0 15.0 15.0 20.0 - - - - - Emulgade® SE Glyceryl stearate (e) Ceteareth 12/20 (e) Cetearyl alcohol (e) Cetyl palmitate - - - - - 5.0 5.0 4.0 - - Eumulgin® B1 Ceteareth-12 - - - - - - - 1.0 - -
    [103] Table 11. Examples of cosmetic compositions (water, preservatives added to 100% by weight) (Continued)
    Composition (INCI) THE B Ç D AND F G Η I J Lameform® TGI Polyglyceryl-3 isostearate 4.0 - Dehymuls® PGPH4.0
    53/56
    Polyglyceryl-2 Dipolihydroxystearate Monomuls® 90-0 18 Glyceryl oleate 2.0 - Cetiol® HE PEG-7 glyceryl cocoate 2.0 - - 2.0 5.0 - - - - 2.0 Cetiol® OE Dicaprilic ether 5.0 6.0 Cetiol® PGLHexildecanol (e) hexildecyl laurate - - - - - - - 3.0 10.0 9.0 Cetiol® SN Cetaryl isononanoate 1.0 - - 0.5 - 3.0 3.0 - - - Cetiol® VDecyl oleate - 1.0 - - , 5 3.0 3.0 - - - Myritol® 318 Coconut caprilate / caprate - - 1.0 - - - - 3.0 5.0 5.0 Beeswax - - - 0.5 0.5 - - - 7.0 5.0 Nutrilan® Elastin E20 Hydrolyzed elastin - - - - - 2.0 - - - - Nutrilan® I-50 Hydrolyzed collagen - - - - 2.0 - 2.0 - - - Gluadin® AGP Hydrolyzed wheat gluten 0.5 0.5 0.5 - - - - 0.5 - - Gluadin® WKSodium cocoil hydrolyzed wheat protein 2.0 2.0 2.0 2.0 5.0 - - - 0.5 0.5 Euperlan® PK 3000 AM Glycol distearate (e) Laureth-4 (e) Cocamidopropyl betai in 5.0 - - 5.0 - - - - - - Arlypon® FLaureth-2 Hydagen® CMF 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
    54/56
    Chitosan Frescolat MGA Mentona Gliceril Acetal 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Glycerin (86 Gew .-% ig) - - - - - 3.0 3.0 5.0 5.0 3.0 A-E = bath lotion, F = soft cream, G, H = moisturizing cream , θ,!, <. =
    night cream [104] Table 12. Examples of cosmetic compositions (water, preservatives added to 100% by weight)
    Composition (INCI) K L M N O P Q R s T Dehymuls® PGPH Polyglyceril-2 dipyrihydroxystearate 4.0 3.0 - 5.0 - - - - - - Lameform® TGI Polyglyceryl-3-isostearate 2.0 1.0 Emulgade® PL 68/50 Cetearyl glycoside (e) cetearyl alcohol - - - - 4.0 - - - 3.0 - Eumulgin® B2 Ceteareth-20 - - - - - - - 2.0 - - Tegocare® PS Polyglyceryl methyl-3 glucose distearate - - 3.0 - - - 4.0 - - - Eumulgin VL 75 Polyglyceryl-2 dipolehydroxystearate (e) lauryl glycoside (e) glycerin - - - - - 3.5 - - 2.5 - Beeswax 3.0 2.0 5.0 2.0 - - - - - - Cutina® GMS Glyceryl stearate - - - - - 2.0 4.0 - - 4.0 Lanette® Cetearyl alcohol - - 2.0 - 2.0 4.0 2.0 4.0 4.0 1.0 Antaron® V 216 Copolymer PVP / he- - - - - - 3.0 - - - 2.0
    55/56
    xadecene Myritol® 818 Cocoglycerides 5.0 - 10, 0 - 8.0 6.0 6.0 - 5.0 5.0 Finsolv® TNC12 / 15 Alkyl Benzoate - 6.0 - 2.0 - - 3.0 - - 2.0 Cetiol® J 600 Oil erucate 7.0 4.0 3.0 5.0 4.0 3.0 3.0 - 5.0 4.0 Cetiol® OE Dicaprilic ether 3.0 - 6.0 8.0 6.0 5.0 4.0 3.0 4.0 6.0 Mineral oil - 4.0 - 4.0 - 2.0 - 1.0 - - Cetiol® PGL Hexadecanol (e) Hexyldecyl laurate - 7.0 3.0 7.0 4.0 - - - 1.0 - Bisabolol 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Frescolat® MGA Mentona Gliceril Acetal 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.09 Hydagen® CMF Chitosan 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Copherol® F 1300 Tocopherol / tocopheryl acetate 0.5 1.0 1.0 2.0 1.0 1.0 1.0 2.0 0.5 2.0 Neo Heliopan® Hydro Phenylbenzimidazole sodium sulfonate 3.0 - - 3.0 - - 2.0 - 2.0 - Neo Heliopan® 303 Octocrileno - 5.0 - - - 4.0 5.0 - - 10.0 Neo Heliopan® BB Benzophenone-3 1.5 - - 2.0 1.5 - - - 2.0 - Neo Heliopan® E 1000 p-isoamyl methoxycinnamate 5.0 - 4.0 - 2.0 2.0 4.0 10.0 - - Neo Heliopan® AV Octyl methoxycinnamate 4.0 - 4.0 3.0 2.0 3.0 4.0 - 10.0 2.0
    56/56
    Uvinul® T 150 Octil triazone 2.0 4.0 3.0 1.0 1.0 1.0 4.0 3.0 3.0 3.0 Zinc oxide - 6.0 6.0 - 4.0 - - - - 5.0 Titanium dioxide - - - - - - - 5.0 - - Glycerin (86 Gew.% Ig) 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0
    Κ - Ν = w / o cream or lotion for sun care, O-T: o / w cream or lotion for sun care
    权利要求:
    Claims (16)
    [1]
    1. Cosmetic composition, characterized by the fact that it comprises:
    (a) Approximately 0.1% to approximately 5% by weight of mentone compounds according to Formula (Ia) or (Ib):
    and (b) Approximately 99.9% to approximately 50% by weight of at least one oil or body wax, (c) Approximately 0 to approximately 25% by weight of at least one emulsifier and / or (d) Approximately to approximately 25 % by weight of at least one active ingredient, with the proviso that the quantities total, together with water and additional ingredients, 100% by weight.
    [2]
    2. Composition according to claim 1, characterized by the fact that compound (a) is glycerol / L-mentone ketal (FEMA GRAS 3807) and glycerol / DL-mentone ketal (FEMA GRAS 3808) or its mixture.
    [3]
    3. Composition according to claim 1, characterized by the fact that body oils (component b1) are selected from the group consisting of alcohol-based Guerbet alcohols having 6 to 18 carbon atoms, esters of C6- acids C22 linear fatty acids with C6-C22 linear or branched fatty acids or esters of C6-C 13 branched carboxylic acids with C6-C22 linear or branched fatty acids, esters of C6-C22 linear fatty acids with branched alcohols, esters of C18- acids C38 alkylhydroxy carboxylics with Οδ-C 22 linear or branched fatty alcohols, this
    Petition 870190063103, of 05/07/2019, p. 10/22
    2/4 linear and / or branched fatty acids with polyhydric alcohols and / or Guerbet alcohols, triglycerides based on Οβ -Cio fatty acids, liquid mixtures of mono- / di / triglycerides based on ΟβCi8 fatty acids, alcohol esters Οβ- C22 fatty and / or alcohols from Guerbet with aromatic carboxylic acids, esters of C2-C12 dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear and branched C6-C22 fatty alcohol carbonates, Guerbet carbonates, based on fatty alcohols having 6 to 18, preferably 8 to 10 carbon atoms, benzoic acid esters with linear and / or branched C6-C22 alcohols, linear or branched, symmetrical or asymmetric dialkyl ethers having 6 to 22 carbon atoms per alkyl group, open ring products of epoxidized fatty acid esters with polyols, silicone oils and / or aliphatic or naphthenic hydrocarbons, mineral oils and mixtures thereof.
    [4]
    4. Composition according to claim 1, characterized by the fact that the waxes (component b2) are selected from the group consisting of super-fatty agents, consistency factors, pearlescent waxes, natural waxes and their mixtures.
    [5]
    5. Composition according to claim 4, characterized by the fact that super fatty agents are selected from the group consisting of lanolin and lecithin, polyethoxylated or acylated lanolin and derivatives of lecithin, fatty acid polyol esters, monoglycerides, alkanolamides of fatty acids and their mixtures.
    [6]
    6. Composition according to claim 4, characterized by the fact that the consistency factors are selected from the group consisting of fatty alcohols, hydroxylated fatty alcohols, partial glycerides, fatty acids and hydroxylated fatty acids having 12 to 22 carbon atoms and their mixtures.
    Petition 870190063103, of 05/07/2019, p. 11/22
    3/4
    [7]
    7. Composition according to claim 5, characterized by the fact that pearlescent waxes are selected from the group consisting of esters of alkylene glycols, alkanolamides of fatty acids, partial glycerides, esters of polybasic carboxylic acids optionally hydroxy-substituted with fatty alcohols containing 6 to 22 carbon atoms, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates containing a total of at least 24 carbon atoms, fatty acids, olefinic epoxide ring opening products containing 12 to 22 carbon atoms with fatty alcohols containing 12 to 22 carbon atoms and / or polyols containing 2 to 15 carbon atoms and 2 to 10 hydroxyl groups and mixtures thereof.
    [8]
    8. Composition according to claim 5, characterized by the fact that natural waxes are selected from the group consisting of candelilla wax, carnauba wax, Japan wax, sparse grass wax, cork wax, guaruma wax , rice oil wax, sugar cane wax, Ouricuri wax, Montana wax, beeswax, shellac wax, spermaceti, lanolin, uropigiana fat, ceresin, ozocerite, petrolatum, paraffin waxes and microceras; Montana ester waxes, Sasol waxes, hydrogenated jojoba waxes, polyalkylene waxes, polyethylene glycol waxes and mixtures thereof.
    [9]
    9. Composition according to claim 1, characterized by the fact that emulsifiers are selected from the group consisting of non-ionic, cationic or amphoteric emulsifiers and their mixtures.
    [10]
    10. Composition according to claim 1, characterized by the fact that it comprises the components in the following quantities:
    (a) 0.3% to 3% by weight of Formula menthol ketals
    Petition 870190063103, of 05/07/2019, p. 12/22
    4/4 (i);
    (b) 95% to 65% by weight of oils and / or body waxes;
    (c) 1 to 15% by weight of emulsifiers;
    (d) 0.5% to 10% by weight of active ingredients;
    with the proviso that the quantities total, together with water and additional ingredients, 100% by weight.
    [11]
    11. Composition according to claim 1, characterized in that the product is an oil in water (o / w) or water in oil (w / o) or multiple oil in water in oil (o / w / o) emulsion or water in oil in water (w / o / w).
    [12]
    12. Composition according to claim 1, characterized by the fact that the product is a lotion, a cream or a stick.
    [13]
    13. Use of menthol ketones according to Formula (I), characterized by the fact that they are stabilizers for cosmetic compositions.
    [14]
    14. Use of menthol ketals according to Formula (I) characterized by the fact that it is to reduce the average particle size of the droplets in an emulsion.
    [15]
    15. Use of menthol kettle according to Formula (I) characterized by the fact that it is to mask the unpleasant odor.
    [16]
    16. Use of menthol kettle according to Formula (I) characterized by the fact that it is used to modify the sensory profile of a stick or deodorant emulsion.
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    同族专利:
    公开号 | 公开日
    US20150190326A1|2015-07-09|
    KR20170063993A|2017-06-08|
    EP2695597A1|2014-02-12|
    MX2015001719A|2017-12-04|
    US9668957B2|2017-06-06|
    MX362655B|2019-01-30|
    BR112015002651A2|2017-07-04|
    JP6067114B2|2017-01-25|
    JP2015524455A|2015-08-24|
    CN104661633B|2019-04-23|
    KR20150038600A|2015-04-08|
    CN104661633A|2015-05-27|
    WO2014023640A2|2014-02-13|
    WO2014023640A3|2014-07-31|
    KR101904684B1|2018-10-04|
    EP3552597A1|2019-10-16|
    EP2695597B1|2019-07-24|
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    法律状态:
    2018-03-06| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2018-03-13| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2018-03-20| B06I| Technical and formal requirements: publication cancelled|Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
    2019-05-07| B06T| Formal requirements before examination|
    2019-07-16| B09A| Decision: intention to grant|
    2019-08-27| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/08/2013, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/08/2013, OBSERVADAS AS CONDICOES LEGAIS |
    优先权:
    申请号 | 申请日 | 专利标题
    EP12179479.6A|EP2695597B1|2012-08-07|2012-08-07|Cosmetic compositions|
    PCT/EP2013/066171|WO2014023640A2|2012-08-07|2013-08-01|Cosmetic compositions|
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